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 How to use Reconstituted Bortezomib Solution (Recon Soln)

This medicine is given by medical staff by intravenous injection or under the skin. If you receive this medication under the skin, make sure to change the injection site every time to reduce the damage under the skin. The dosage depends on your size, medical condition, laboratory tests and response to treatment.

To prevent dehydration, be sure to drink plenty of fluids when using this medication. If you have any questions, please consult your doctor or pharmacist.

Side Effect

Dizziness, dizziness, nausea, vomiting, loss of appetite, diarrhea, constipation, fatigue, weakness or pain/redness may occur at the injection site. Nausea, vomiting and diarrhea can be severe. In some cases, your doctor may prescribe medications to prevent or relieve nausea, vomiting, and diarrhea. If these effects persist or worsen, please inform your doctor or pharmacist immediately.

To reduce the risk of dizziness and dizziness, stand up slowly when lifting from a sitting or lying position.

People who use this drug may have serious side effects. However, your doctor prescribes this medicine because he or she believes that the benefits to you outweigh the risks of side effects. The doctor's careful monitoring may reduce your risk.

Bortezomib sometimes causes side effects (tumor lysis syndrome) due to the rapid destruction of cancer cells. To reduce the risk, your doctor may add medicine and tell you to drink plenty of water. Tell your doctor immediately if you have the following symptoms: lower back/side pain (lower back pain), signs of kidney problems (such as painful urination, pink/bloody urine, changes in urine output), muscle cramps/weakness.

If you have any serious side effects, please tell your doctor immediately, including: tingling/numbness/pain/arm/leg fever, syncope, severe headache, mental/mood changes (such as confusion), severe abdominal/abdominal pain, signs of liver disease (E.g. yellow eyes/skin, yellow urine), heart failure symptoms (e.g. shortness of breath, swelling of ankles/feet, abnormal tiredness, abnormal weight/sudden increase).

If you have any very serious side effects, seek medical help immediately, including: chest pain, difficulty breathing, vision changes, seizures, weakness on one side of the body, and difficulty speaking.

This medication can reduce blood cells, which can cause anemia, reduce the body's ability to fight infections or cause easy bruising/bleeding. If you experience any of the following symptoms, please tell your doctor immediately: easy bleeding/bruising, black/tar-like stools, vomiting that looks like coffee grounds, signs of infection (such as symptoms such as throat not disappearing, fever, chills, etc.) ), abnormal tiredness, pale skin.

Very severe allergic reactions to this drug are rare. However, if you notice any symptoms of a severe allergic reaction, including skin rash, itching/swelling (especially face/tongue/throat), severe dizziness, and difficulty breathing, please seek medical help immediately.

Bortezomib usually causes a rash, which is usually not serious. However, with the exception of a rare rash, you may not be able to tell it, which may be a sign of a serious reaction. If a rash occurs, seek medical help immediately.

Precaution

Before using this medicine, tell your doctor or pharmacist if you are allergic to it; or if you have other allergic reactions. The product may contain inactive ingredients (such as boron, mannitol), which may cause allergic reactions or other problems. Contact your pharmacist for more details.

Before using this medication, please tell your doctor or pharmacist your medical history, especially: nerve problems (such as peripheral neuropathy), liver disease, kidney disease, excessive body water (dehydration), heart disease (such as heart failure) ), bleeding/blood diseases, current/recent infections, diabetes.

This medicine may make you dizzy. Alcohol or marijuana (marijuana) can make you more dizzy. Before operating safely, do not drive, use machinery or perform any operations that require vigilance. Limit alcoholic beverages. If you use marijuana (marijuana), consult your doctor.

Before having surgery, please inform your doctor or dentist of all the products you use (including prescription drugs, over-the-counter drugs, and herbal products).

Bortezomib can make you more susceptible to infection or may worsen your current infection. Avoid contact with infected people who may spread to others (such as chickenpox, measles, flu). If you are infected or for more detailed information, please consult your doctor.

Do not get immunizations without the consent of your doctor. Avoid contact with people who have recently received live vaccines (such as flu vaccine inhaled through the nose).

To reduce the chance of cuts, abrasions, or injuries, be careful with sharp objects such as razors and nail clippers, and avoid activities such as contact sports.

Tell the doctor if you are pregnant or plan to become pregnant. You should have a pregnancy test before you start using this medication. You should not become pregnant while using bortezomib. Bortezomib may harm an unborn baby. Women should ask about reliable forms of birth control while using this drug and within 7 months after stopping treatment. Men should ask about reliable forms of birth control while using this drug and within 4 months after stopping treatment. If you or your partner is pregnant, talk to your doctor immediately about the risks and benefits of this medication.

Whether the drug passes into breast milk is unclear. Because it may be dangerous to the baby, it is not recommended to breastfeed while using the drug and within two months after stopping the use of the drug. Consult your doctor before breastfeeding.

Consult your pharmacist or physician.

Interactive

Drug interactions may change the way drugs work or increase the risk of serious side effects. This document does not include all possible drug interactions. Keep a list of all products you use (including prescription/over-the-counter drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop or change the dosage of any medicine without the permission of your doctor.

Other drugs may affect the removal of bortezomib from the body, which may affect the way bortezomib works. Examples include rifamycin (such as rifabutin), St. John's wort, drugs used to treat seizures (such as carbamazepine, phenytoin), and the like.

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